Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA
نویسندگان
چکیده
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.
منابع مشابه
CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species.
B cells and monocytes endocytose DNA into an acidified intracellular compartment. If this DNA contains unmethylated CpG dinucleotides in particular base contexts (CpG motifs), these leukocytes are rapidly activated. We now show that both B cell and monocyte-like cell line responses to DNA containing CpG motifs (CpG DNA) are sensitive to endosomal acidification inhibitors; they are completely bl...
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ورودعنوان ژورنال:
- Arthritis Research
دوره 3 شماره
صفحات -
تاریخ انتشار 2001